Spider-Man's latest iteration, as a wise-cracking teen web-slinger embedded in the Marvel Cinematic Universe, might be the most successful yet. With great power and great responsibility comes a need for great villains to face, and fortunately among Marvel's several thousand published characters are more than a few who specialise in beating down on the web-headed wonder.
As well as encountering classic Marvel villains at every turn, Spider-Man has also tussled with villains associated primarily with him or with the urban New York-based heroes including Spidey and Daredevil.
Spider-Man's tangling with the Vulture and his associates was only the beginning for the new cinematic Spidey. The choice of villain will have a massive influence on the feeling and quality of future instalments in Peter Parker's story, not just by giving him someone cool to fight but by enabling powerful themes to be explored and some particularly well-regarded comic book arcs to be adapted.
Some villains are prominent members of Spider-Man's rogues' gallery, while others are less well-known by the public but have particular utility in the MCU. And some are just plain cool.