TMZ are reporting that comedy legend Harold Ramis has died, aged 69. The Hollywood actor/writer/director who is probably best known for the classic 80s and 90s films Animal House, Caddyshack, Ghostbusters and Groundhog Day, among many others, reportedly passed away early this morning at his Chicago Home. TMZ report that Ramis' family confirmed his passing from "complications stemming from autoimmune inflammatory vasculitis, a rare disease involving the swelling of blood vessels." His whole family were said to be present and Ramis is now survived by his wife Erica, his two sons Julian and Daniel and also his daughter Violet, along with two grandchildren. Ramis had been suffering from health issues related to his disease for the past four years. He had not directed a movie since 2009's Year One as he continued to battle the disease, although he was always thought to be attached to the Ghostbusters 3 developments at Sony, largely spearheaded by friend/co-star/co-writer Dan Aykroyd. Along with the movies listed above, Ramis also directed National Lampoon's Vacation, Bedazzled, Analyze This and was part of many of his movies which also received sequels. He will be sorely missed by the editors of WhatCulture.com who grew up with his work and began to idolise American comedy cinema, thanks in many part due to work he was involved in.