With the passage of time and the dormancy of the series having prevented a long-term narrative from forming to keep fans waiting to see what happens next, the revival of the Dino Crisis series could potentially go anywhere with its premise and storytelling. In the most likely option at this point, the series could easily go down the reboot route, either retelling an updated version of the original game's story in and around the Ibis Island facility to bring its Third Energy concepts back into the fold or settling on a new location or distorted time period all while reintroducing series star Regina to new fans who either never had the chance to play it or were not alive when the series started. It could also simply take place sometime after Dino Crisis 2, with the events of the first two games coloring the backstory of a new game, not requiring new fans to have played them to find the new story easily accessible while giving old fans some acknowledgment and closure, particularly with finding out if Regina was able to fulfill her promise to Dylan in the closing moments of its predecessor. Whether it's a reboot, sequel or something else entirely, a new Dino Crisis game at this point would ultimately have to focus on making countless new fans. Fortunately, the series hasn't been and never was locked down to a particular story point beyond the involvement of Third Energy, which gives any future narratives a lot of room to play around with.