45. Shodan (System Shock 2)
Take a crazed super computer with an unrelenting desire for mission fulfillment regardless of the cost, wrap it in a smooth female voice and BOOM, Shodans here to terrify all! Her likes include, referring to you as an insect at all times as you run away from this Sci-Fi landscape, while intimidating you and belittling you at every turn, constantly trying to rationalize your demise. Shes also a modest gal, quick to tell you how untouchable she is and the power she holds. Clearly a big inspiration to a certain future games evil robot which may be discussed later on.
44. Le Chuck (Monkey Island Series)
What makes this salty old sea dog such a hardcore pirate to deal with is his inability to die! No matter how many times you kill him, hell be back. Le chuck is the embodiment of how strong love is, it can even kill you! Obsessed with the beautiful and powerful Elaine Marley, governor of the islands Melee, Plunder and Booty, he proposes to her and is swiftly rejected. Unfortunately shortly after this he feels the bitter taste of death, not one to give up as a ghost hes still set on finishing his goal. In fact throughout the Monkey Island series Le Chuck has been through a number of different forms from a ghost to a zombie even a demon!.....ahem, before being TAH-DAH, human again!
43. Bob The Killer Goldfish (Earthworm Jim 1&2)
Bob is the foulest, most evil and devilishly deviant miscreant youll ever have the misfortune of meeting... but he is unfortunately a goldfish, clearly a large intrusion into his plans for world domination. Bob spends majority of his time floating in his bowl atop the shoulder of a muscle bound behemoth of a feline known only as number four, shouting and ranting evil orders at will! He may seem like a simple character but with each boss battle being over the top affairs with hilarious anti-climactic endings youll never forget your meetings with Bob.
42. Nazis (Every FPS Ever)
Lets face it, theres no way you could have a list of video game villains without mentioning Nazis, practically every war game ever made has Nazis somewhere. So why do these characters make such great enemies and so pleasurable to kill for gamers? With a clear and widely known back story, using Nazis as enemies allows games to avoid wasting time explaining exactly why you are fighting, and due to nazis over the years being painted using broad strokes as comic book villains, it allows players to be as black and white as possible theyre evil! Kill them all! The other point to bear in mind is that german soldiers were well trained and well equipped, making for a good video gaming challenge, from shoot outs in crowded streets or corridors to high flying dog fights over head youll have a tough fight on your hands.
41. Dracula (Castlevania)
Bram Stoker is responsible for giving birth to one of the worlds most recognized villains of all time, and the gaming world has definitely built upon this character and ran with it, constantly making him more powerful or more monstrous and even more deviant, but its the Castlevania series which has stuck by this villain for years and made the undead the classic many gamers will always remember. The plot behind many Castlevania games were all relatively similar, usually revolving around count Dracula rising from the dead once more, bringing hellish demons and minions with him to terrorize Eastern europe on his quest for blood. This left the Belmont family, a long line of vampire hunters, to constantly do battle with Dracula and his forces to protect everyone from the threat of the vampire beast. A persistent and somehow still always an exciting villain, Dracula is an important gaming baddie.