If there's any one franchise associated with the ol' rumpy pumpy, it's Leisure Suit Larr- it's Mass Effect.
Since the 2007 original and all the way through to Andromeda, Bioware have totally owned the philosophy of Jay's aspirational vision of the future from Clerks II - "I'd be the first to find a new galaxy or a new alien life form... and f*ck it."
To be fair, Bioware have extended this notion of interspecies erotica across every subsequent release, gaining a reputation in the industry for showcasing all manner of tendril/horned/fleshy part-focused sex scenes. 2014's Dragon Age Inquisition let you romance a mound of muscle known as Iron Bull; ostensibly a centaur with the voice of a baritone sex God, and going into Mass Effect Andromeda, the game's rating classification was upped to allow for full nudity, the devs literally calling it "softcore space porn."
Talk about being self-aware.
Whilst I doubt anyone's going into a Mass Effect just for alien-banging, Bioware's various expo panels and pre-launch discussions were dominated by questions surrounding how sex scenes would be portrayed, making for a hilarious realisation when it's clear they spent FAR more time on them, than even the base facial animations...