It was rumored to happen, but you definitely forget about Johnny Depp popping up somewhere in a cameo role while you're watching all the hilarity that is 21 Jump Street. And when Depp does show up, he's not only paying homage to his time on the show (by doing something his character would be doing), but he also gets a send-off with fellow actor Peter DeLuise to keep them from any sequels. Should cameos count as "twists?" Not in the traditional sense, as this didn't change the movie in any specific way, but it was the perfect way to cameo a part, and the reveal was certainly worth cheering for, even if you had never watched the show to begin with.