10 Villains Spider-Man Has NEVER Defeated

10. Thanos

At the bottom of this list is, naturally, its least surprising entry. Shock of all shocks, the mad titan has never felt threatened by the kid from Queens in a red and blue body stocking.

Which is not to say that Thanos and Spidey haven't fought multiple times. it's just that every time they have, Peter has been at best an afterthought while Thanos takes on the bigger heroes that have come with Spider-Man.

The most famous time that these two have come to blows has, of course, been the original Infinity Gauntlet event comic, where Thanos attained the Infinity Gauntlet and gems to ascend to a higher plane of existence, and all to get Death-senpai to notice him. Spider-Man is among the many heroes recruited by Adam Warlock to act as meat shield distractions for Thanos so that Adam can find a way to get the gauntlet off of him.

Yeah, as you can probably surmise, Spidey does not last long. Thanos isn't even the one who kills him, instead outsourcing that to his artificial henchwoman Terraxia.