Mystique is best known as an enemy of the X-men, specifically due to her difficult relationship with many of the team's members including Nightcrawler and Rogue. But prior to becoming a long-time enemy of the X-men, Mystique was the main foe of both super-heroine Miss Marvel and S.H.I.E.L.D. commander Nick Fury, battling the pair from 1978 onwards. It was Mystique's enmity with Ms Marvel that led to her adopted daughter Rogue eventually joining the X-Men. In an attempt to get rid of the hero, Mystique uses Rogue to absorb Miss Marvel's powers, together with her psyche. This led to the then-evil Rogue experiencing a severe mental breakdown due to the strength of Ms Marvel's personality, and turning to Charles Xavier for help.