50 Funniest Comedy Movie Moments Since 2000

50. The Wolf Attacks - Tim And Eric's Billion Dollar Movie (2012)

The Movie: Would-be filmmakers Tim (Tim Heidecker) and Eric (Eric Wareheim) get a billion dollars to make a movie, only to watch their dream run off course. In order to make the money back, they then attempt to revitalize a failing shopping mall.

The Scene: When a wolf begins to terrorize the mall, resident man-child, Taquito (John C. Reilly), decides to step up to the plate and sacrifice his life for the good of the establishment. He indeed manages to kill the wolf and save the day but becomes fatally injured in the process. 

 This touching moment ends with the mall's owner and Taquito's best friend (Will Ferrell) attempting to put his pal out of his misery. This turns out to be easier said than done as he nearly empties an entire clip into his body to (almost) no avail.

Memorable Quote: "Tell you what Taquito, we're gonna change the name of the pizza court to Taquito court. You hear me?"