Another long-term enemy of the Fantastic Four, Annihilus is the ruler of the Negative Zone, the parallel dimension where the Fantastic Four gain their powers in the upcoming film. Basically a giant, humanoid insect, Annihilus has access to advanced technology, can survive in the vacuum of space, and leads the Annihilation Wave, an almost-endless hoard of alien insect monsters. Not only is he ridiculously strong on his own, Annihilus's also wields the Cosmic Control Rod, which allows him to manipulate cosmic energy and the molecular structure of matter. The appearance of Annihilus is basically already worked into the story-line of a Fantastic Four franchise. The team get their powers by travelling into the Negative Zone. Annihilus comes from the Negative Zone. You do the maths. Plus, including an item called the Cosmic Control Rod in a film can only lead to great games of innuendo bingo.