MCU: What Happened To Everyone Who Held The Mind Stone?
8. Loki
The first time the Mind Stone is seen in the MCU was in 2012's The Avengers. Loki showed up to an underground S.H.I.E.L.D. research facility to collect the Tesseract, which was later revealed to be a housing for the Space Stone.
Loki's appearance also marked the first appearance of the Mind Stone, though it was housed within a blue container at the end of a Scepter the God of Mischief had as his primary weapon.
It is revealed that the Scepter was given to Loki by none other than Thanos himself, which suggests that Thanos held the Mind Stone first. Since this was not shown at any point in the films leading up to The Avengers, Loki holds the distinction as being the first to wield the Infinity Stone in the MCU.
He used it to take control of anyone he touched the point of the Scepter to so long as he placed it on their heart. This was used to take control of a number of scientists and S.H.I.E.L.D. agents, most notably, Hawkeye. Loki would later attempt to take control of Tony Stark in the same way, but it failed to work as he had an Arc Reactor in his chest, clocking his heart. Eventually, Loki was defeated, and the Scepter (Along with the Mind Stone) was passed to its next recipient.