10 Best Final Bosses In Resident Evil History

10. Resident Evil 0 - Leech Queen

Rather fittingly for a game presented as an origin story, the Leech Queen in Resident Evil 0 provides a quintissential example of a Resident Evil-style final boss fight. Many of the tropes found throughout the series' climactic duels are present and correct here: a tight time-limit, a mutated version of the game's primary antagonist and (somewhat irritatingly) the killing blow being delivered in a cutscene.

However, the fight does have one major gimmick to differentiate it from standard Resi fare. Unlike a normal boss battle, you aren't expected to shoot the Leech Queen until she runs out of health.

Instead, the entire fight sees you running distraction as one-game wonder Billy Coen, while Rebecca Chambers of RE1 fame runs around the arena turning valves bring in the age of aquarius and let the sunlight in. (Showing our age with that reference...)

It's an interesting take on a boss battle, and a smart use of Zero's co-op gimmick by giving both characters equally vital tasks to take the Queen down. It might not be the best fight on this list, but its smart use of its game's central hook definitely make it one of the most unique.