1. Seth Green Jeff "Joker" Moreau in Mass Effect
Its fair to say that Seth Green has spread himself far and wide in projects both awesome and awe-less, but few would disagree that one of his finest hours is as Joker in the Mass Effect trilogy. Green's natural sarcastic wit really translates into the game, giving the character life and realism that would be sorely missed in the wrong hands. Green's performance really gives us a taste for this chip-on-shoulder badass character.