Saying goodbye to Aeris was probably one of the most difficult things I've ever had to do in a video game, despite the fact that for the most part you're not even in control of Cloud. If you're a fan of the series, you'll know exactly what I mean. Aeris was pure, she was innocent - probably the person in the rag tag group of eco-warriors that deserved to die the least. But die she did and even though she isn't real, it was f***ing heart-breaking. The above image is the final moment, the "I'll never let go, Jack" that makes the lump appear in the throat, that makes grown men suddenly get "something in their eye". I certainly can't think of a more emotionally resonant gaming moment, if there even is one. For that, and for the game's immense popularity of course, the above image earns an easy place in this list.