10 Greatest Comedy Duos Of All Time

10. Will Ferrell & John C. Reilly

On one side, you have Will Ferrell, an actor who spent his entire career working in comedy. On the other, John C. Reilly, a man who worked tirelessly to make it as a serious, dramatic actor before doing a complete 180 and becoming one of the funniest comedic actors of his day (After meeting Ferrell). Together, they are a modern comedy duo who work so well together, it's difficult to imagine them working apart.

Fortunately, that's not a major concern as these two funnymen have collaborated on dozens of projects with another set to drop in late 2018.

Interestingly, it was Ferrell who pulled Reilly from the world of dramatic acting and into comedy with the film that is arguably their best collaboration: Step Brothers.

Ferrell refused to even work on the project unless his pal could star opposite him. Fortunately, the producers decided to work with him and cast Reilly. That wasn't their first time working together on screen, but it was their most notable buddy comedy picture, which may see something of a spiritual sequel in Holmes & Watson when it hits theaters on Christmas day, 2018.