Howard and Berndette's ending may not be the singular most important storyline to wrap up, but it could be a huge catalyst for change among the group with the end approaching. Bernadette's pregnant, but you can expect the baby to be a big feature of Season 10, rather than the pregnancy itself. I'm fully expecting Howard to earn his doctorate by the end of the season, however that may come about, but I don't think we're finished with astro-Wolowitz just yet. He may need to move elsewhere in the country to be closer to a launch site (Florida, Texas...) and it would be an exciting end for the fledgling Wolowitz family if that were to happen.