Maybe its only appropriate that Skyler White serve as the introductory entry to this list. Long reviled by Breaking Bad audiences, Skyler functioned as basically the show's unofficial antagonist - especially in the later seasons. Now, to some degree this, hatred is unfair. Skyler was in many ways a victim of circumstance, forced to confront the very real possibility of her family's complete destruction. However, this doesn't change the fact that she was often insufferable to watch, and that her attempts to exert some control over her life were basically ineffectual. From the affair with Ted Beneke, to her decision to become Walter's accomplice in Season 3, nearly everything this woman did throughout the series made her progressively more miserable. And frankly that is an incredibly frustrating thing to observe.