A Dire Wolf is to a wolf what a Giant is to a man. Roughly the size of a horse, a full-grown Dire Wolf is around twice the size of its real life counterpart while a 12-14 foot Giant is double the size of a very large man. Though both the fantastical creatures from the northern wastes of Westeros are incredibly fearsome, we have to say that a wolf is more dangerous than a man, so by extension a Dire Wolf could defeat a Giant. Defined by their ferocity, razor-sharp teeth and blistering speed, Dire Wolves are quite rightly some of the most feared creatures in the north, despite the Starks proving that they could be tamed to a degree. Though the immeasurable strength of a Giant would be more than enough to kill a Dire Wolf if they got ahold of one, we believe that the agility and swiftness of the Starks sigil creature would allow them to avoid the Giants clumsy attacks and to grab onto a limb with those terrifying jaws. Indeed, even compared to worldly wolves teeth, Dire Wolf fangs are described as being proportionately far larger. Having grabbed a limb the Dire Wolf would be able to rag-doll the Giant to the ground using all that explosive muscular power before mauling it to death in the savage style the shows creators are so fond of.