This leads into discussion about the acromegaly - also known as gigantism - caused by overdevelopment of the pituitary gland. He points out that Andre The Giant had it, as well as The Great Khali. Show says he's the textbook definition of a giant, and after his medical procedure to have it fixed, he's now extended his lifespan to that of normal people. He describes how the tumor affects the different hormones in your body to cause the massive growth, and says that 176 kids per year graduate from high school with acromegaly. Jericho talks about Giant Gonzalez and how badly the condition affected him, and says that when they were in Japan he had to use Ultimo Dragon as a human cane just to get around. Show says he came from a big family and was going to be large anyway and was lucky enough to have a body that was prepared for it, and says it's a brutal disease when not caught early. He says that he got very lucky because he got a lot of the benefits - such as increased bone density - while dodging most of the side effects.