8 Video Game Protagonists You Fought In The Sequel

8. Alex Mercer - Prototype 2

Alex Mercer is the protagonist of the original Prototype, yet for the sequel the decision was made to introduce a new player character - ex-U.S. Marine Sergeant James Heller.

But in a fun twist, Heller finds himself hunting down Mercer after Mercer vows to wipe out humanity with a new outbreak of the Blacklight virus, which Heller believes is responsible for the death of his family.

During their first clash, however, Heller is infected with the virus and develops superhuman abilities similar to Mercer. 

And so, you can probably see where things are going from here.

Prototype 2's final boss fight is a superpowered grudge match between the two, each throwing everything that they have at the other until Heller finally defeats and consumes Mercer, in turn absorbing all of his accrued knowledge and memories.

That's... one hell of a definitive way to slam the door on the original protagonist, that's for sure.