Sherlock Season 4: 20 Easter Eggs & References In 'The Final Problem'
14. Baker Street On Fire
In a tense scene, Sherlock, John and Mycroft are caught in a blast from a drone carrying a "patience grenade" that destroys 221B Baker Street. This is a dramatized version of an incident mentioned in passing in Doyle's The Final Problem.
When on the run from Professor Moriarty, Holmes explains to Watson that the criminal "set fire to our rooms last night." This incident was also referenced in The Great Game, when Moriarty sets off a bomb across the street from 221B.