As with several other directors on this list - especially Cronenberg and Jodorowsky - David Lynch has built his reputation on films that welcome multiple readings and interpretations. Nearly any movie from his filmography could fit in this slot, perhaps with the exception of his godawful Dune adaptation (which, coincidentally enough, is at the heart of a new documentary about Jodorowsky's doomed version). It's odd to call Lynch's 2001 film Mulholland Drive accessible, but the structure and overall aesthetic of the film really is quite endearing. It's certainly more likeable than Lynch's first film Eraserhead, while still boasting a relatively similar degree of impermeability. Set across California, Mulholland Drive begins with a car crash that leaves a woman unsure of her own identity. Several strange occurrences and visuals leak out of a more-or-less "normal" storyat least at first. By the third act of the film Lynch has opened the floodgates and dared you to try to wrap your head around it. Several LOST alumni - it being the television show most comfortable in the company of these complex films - appear in Mulholland Drive, including Mark Pellegrino and Patrick Fischler. Their appearance in both works is a coincidenceor is it?