10 Movie & TV Spoilers We Didn't Know Last Week (22nd June)
4. The Plot Of The New Ghostbusters Movie Is A Bit Different From The Original (Sort Of)

"Wiig and McCarthy play a pair of unheralded authors who write a book positing that ghosts are real. Flash forward a few years and Wiig lands a prestigious teaching position at Columbia University. (Like the original, the story takes place in New York City, even though its being shot in Boston.) Which is pretty sweet, until her book resurfaces and she is laughed out of academia.
Wiig reunites with McCarthy and the other two proton pack-packing phantom wranglers, and she gets some sweet revenge when ghosts invade Manhattan and she and her team have to save the world."
Elements of the old plot, then (with the main characters getting fired from their university jobs), mixed with some new aspects - like Wiig and McCarthy's characters having written a book about ghosts and such. All in all, the whole thing sounds rather promising, actually.