6. Rhys Ifans
Always known as quite an eccentric, odd part playing actor, Rhys Ifans could bring something really edgy and interesting to The Lizard in a way certain villains ("Spider-Man 3"...Oh my god Spider-Man 3) have failed to do in the past. Certain things about him shown in the trailer make it feel like his eccentricities have been reigned in, hopefully however as he starts to make the transition into Lizard he will devolve into something much more odd and eccentric and we could have a truly captivating villain on our hands.