10. 50 Cent - Things Fall Apart (2011)
50 Cent is known more for rapping about birthdays and getting shot a whole bunch of times than for acting. So when the rapper-turned-actor revealed his astonishing weight loss for his role as a cancer victim in All Things Fall Apart, the media world was pretty shocked. Mr. Cent dropped a reported 50 pounds from his tough physique to make the film, making use of a liquid diet and exercising for over three hours a day. It's kind of a shame no one saw the film.