50 Funniest Comedy Movie Moments Since 2000

The Movie: Walk Hard tells the up-and-down-and-up-again story of musician Dewey Cox (John C. Reilly), whose songs would change a nation. 

On his rock 'n roll spiral, Cox sleeps with 411 women, marries three times, has 36 kids, stars in his own 70s TV show, collects friends ranging from Elvis to the Beatles to a chimp, and gets addicted to - and then kicks - every drug known to man.

The Scene: Technically it's a collection of scenes as opposed to a single moment, the audience gets to watch as Dewey makes the transition from smoking weed, to cocaine, to pills to medication for erectile dysfunction.

Memorable Quote: "Get out of here, Dewey. You don't want no part of this sh*t."