50 Funniest Comedy Movie Moments Since 2000

The Movie: Kristen Wiig stars as Annie, who suffers a series of misfortunes after being asked to serve as maid of honor for her best friend, Lillian, played by Maya Rudolph.

The Scene: During the plane ride to Lillian's wedding, and after accepting a sedative due to her fear of flying, Annie becomes quite belligerent. Sneaking from her coach seat to first class (where the rest of her friends are), Annie makes quite the spectacle of herself. 

Many people will cite Bridesmaid's food poisoning scene as the most memorable, but watching Kirsten Wiig mispronounce a flight attendant name Steve for "Stove" is pure comedy gold.

Memorable Quote: "You can't get anywhere in three seconds. You're setting me up for a loss already."