Avengers: Infinity War - Predicting All 76 Characters
58. T'Challa/Black Panther (Chadwick Boseman)

Status: Confirmed
As the first trailer confirmed, Wakanda will play a seriously key role in Infinity War, with the Soul Stone expected to be found there in Black Panther's stand-alone (possibly giving the Wakandan magical herb its powers). That means open war between the Wakandan alliance (including some of the Avengers) and Thanos' alien army and T'Challa at the head of the frontline.
By then, we will have seen him finding his feet as the new leader of his country and dealing with the rising threat of Erik Killmonger, and it will no doubt fall to him to unite the warring tribes to help fight against the invaders.
57. Okoye (Danai Gurira)

Status: Confirmed
With the film taking a tour of Wakanda, whoever survives Black Panther will appear in Infinity War and we've already had confirmation that Danai Gurira's Okoye - the head of his personal security detail - will be back to fight by his side.
56. Shuri (Letitia Wright)

Status: Confirmed
And where T'Challa's head of security is, so too comes his head of technology. Shuri is set to be the Wakandan Tony Stark, capable of inventing anything as long as she has the materials - and it will likely be her hands that craft Bucky's new arm and Cap's new Vibranium shield.
Let's hope we get to see some of her impressive gadgets in action against Thanos' army.