8 Video Game Villains Destroyed By Their Own Creations
2. Nearly Every Zombie And Bioweapon - Resident Evil Franchise
It might seem a very vague statement to say that nearly every single compound of the T, G and every other virus produced by Umbrella and Tricell has come back to bite them in the ass, but it's hard not to look at the smouldering remains of several underground labs, the ruination of entire cities, and of course the absolute nosedive of their stock when they were outed as being responsible, and say the companies are doing well.
On a more personal level, Oswald E. Spencer was given a thorough chest exam by his own super solider and hope for immortality Albert Wesker, and the Tyrant R rebelled against its creators, despite being fitted with devices specifically to stop it from doing that.
The most frequent defeat that nearly every villain deals themselves is when each decides to inject a bit of that sweet, sweet virus into their veins.
In this moment, they've already lost, as the extreme mutation that then occurs destroys their lives entirely, as now they are part of it rather than the other way around, and become absolutely ruined in the pursuit of power.