Uncharted: 10 Spin-Offs Fans Would LOVE
2. Cassie & Nate
While Sam and Sully is one of the more obvious options for a spin off from the conclusion of A Thief's End, the other direction that was clearly set up was that of Nate and Elena's daughter. The game's epilogue introduces Cassie as an almost certain playable character in the future.
As the daughter of the franchise's two main characters, Cassie became a natural explorer, even going so far as to appear on the cover of Adventure Life magazine. While her parents had been open about their expeditions through D&F Fortunes with her, they had kept their past a secret for years.
When Cassie finally discovered the literal skeletons in her dad's closet, Nate launched into the story of finding El Dorado, and his daughter was captivated. It seems like there would be nothing Cassie would like to do more than go in search of an ancient mystery with her dad.
Of course, for this potential game, Nate would be employed as an NPC, taking the role usually occupied by Sully or Elena, while passing the torch on to Cassie to take over the franchise. If she's anywhere close to as witty or as smart-mouthed as Nathan Drake, she will make for a charming, compelling protagonist.