10 Most Irredeemable Star Trek Villains
7. Winn Adami
Admittedly, this Ranjen then Vedek then Kai wasn't all bad; she had a few things going for her. During the Occupation, she risked her life, and was imprisoned, for preaching her faith, and saved a number of lives, once by bribing a Cardassian officer to divert a transport of Bajorans headed for execution. Plus, perhaps if the Prophets (presumably because they’d already seen her entire 'career' path) hadn't wanted her to end up siding with the Kosst Amojan, they might have not let it go to Celestial Temple voicemail every time she tried to call.
Still, in spite of the above, and after carefully considering her (turncoat) tactics in the Fire Caves — switching sides really only because Dukat had gained the upper hand — Winn Adami remains a character past the point of redemption. She stabbed poor Solbor quite literally in the back, for Prophets' sake, and did so in the more metaphorical sense to plenty of others who got in her way.
Winn shunned Sisko from the very beginning, unwilling to accept (until a lot later) that a 'non-believer' could be designated Emissary of the Prophets. She fought Keiko O’Brien for teaching science, which was all just a ruse to try to assassinate Vedek Bareil (now that’s blasphemy!), further connived her way to becoming Kai, took credit where none was due, and sent in the militia over a few reclamators. Later, she interrupted the Reckoning, and then nearly set Bajor and the rest of the galaxy on fire by attempting to release the Pah-Wraiths.