2. Make It A Good Ship
The general public expect a Star Trek show to be set on a ship. This was a problem which faced the producers of Enterprise who wanted to have the first season to build up to the launch of the ship, but the studio wanted the crew out amongst the stars immediately. Any new series is going to have this same issue the non-Trekkies will expect the series to be about the Enterprise. The problem is that with the Abrams film series about, I'm sure that CBS will have an issue with the films and television series both portraying different versions of a ship with the same name. And let's be honest we're not going to get the film Enterprise cast to sign on for a six or seven year television series. Financially it is not in their best interests. The ship itself need not be the best, or the fastest in the fleet in fact, if it's a run-down old rust bucket then it'll help to characterise the hard working engineering team who manage to keep the thing running. But we are also no longer constricted by the use of models either so the ship can be damaged, it can be refitted and changed over time and improved. Design can also be taken in a different direction if needed sure there will be traditionalists who complain about the most mundane of things, but even the design changes between the periods seen in Enterprise and The Original Series can be explained away by saying that the earlier series was designed along the lines of how humans would imagine it, and The Original Series design elements were influenced by a number of alien races within the Federation. New design changes to a new series could also be explained away using the same method with new races joining the Federation all the time and different influential members sitting on in important roles within the senior levels of Starfleet. What I'm saying is that a new series shouldn't be afraid to take the ship and mix it up a little. Keep the viewers on their toes because then they'll keep watching.