4. Dr Mephesto (South Park)
South Park's Dr. Mephesto is a genetic engineer who has a lab in the town. He was initially a parody of Marlon Brando in "The Island of Dr. Moreau." His major field of expertise within the world of genetics is putting extra asses on various animals. For example a four assed monkey, a four assed mongoose, a four assed frog and his crowning achievement the seven assed Galapagos turtle. In early episodes, he also produced a gaggle of angry turkeys and a town-smashing clone of Stan. Mephesto proved at every opportunity that he was indeed a mad scientist, not of any real use to the town or anyone. After season one, Mephesto was relegated to being more of a background character, making only sporadic appearances on the show.