20 Best TV Comedy Shows Of The 21st Century

A more ambitious and occasionally experimental single camera sitcom, the hospital-set Scrubs offered a mash up of medical drama and traditional comedy which allowed it to hit emotionally devastating places few sitcoms are able to handle, whilst always able to fall back on its hilarious cast for comic relief.

The superb chemistry between leads Zach Braff and Sarah Chalke, as a pair of doctors entangled in an on-off relationship, kept us coming back, but each individual instalment of this series benefited from a charming supporting cast including the always underrated John C. Reilly and a whole host of eccentric bit parts for comic talents, whilst its serious setting was always on hand to anchor the surreal humour with some emotional heft.