Agents Of SHIELD: 8 Ways It Sets Up Marvel's Inhumans
4. S.H.I.E.L.D. Knows About Them
The Inhumans arent out in the open, and that doesnt seem like changing anytime soon, but the fact that SHIELD is not only aware of them, but actively trying to track them down, could be very significant for the future.
While SHIELD will be doing their best to keep it a secret, and they arent quite the all-powerful organisation they used to be, there is still a danger that the information could fall into the wrong hands, for instance Hydra. They would surely love to be able to find and use Inhumans for their own purpose.
Also, there are still clear links between SHIELD and the Avengers, mostly through Coulson and Nicky Fury or Maria Hill. With the fact that all of the Marvel films connect some way, then this link may be an indication of just how the Inhumans of the movie tie into the rest of the MCU and in particular the Avengers.