4. Meg
Okay, let's face it, this was never going to happen. Again, though, Meg's death (the inevitable suicide that we've all seen coming for the last decade) would have made for an intriguing plot, and panders to Family Guy's typically-dark subject matter. Meg is consistently abused by her family. Whether it's Peter farting in her face or Lois having an affair with one of her (rare) boyfriends, she's pretty much treated like garbage by the Griffins. In the season 8 episode of Family Guy, 'Dog Gone', Brian runs over a dog (ironically) and is cut up about it, even confessing to his family in front of neighbour and police officer Joe Swanson. Expecting to be arrested, it instead transpires nobody cares, and Brian starts to feel depressed by the thought that his life is meaningless - that is, until Stewie fakes Brian's death to make the rest of the family realise how much they'd miss him. I would have liked to have seen a similar idea extended to Meg, for it would have been touching for the Griffins to finally realise how horrible they were toward her, and that they in fact miss her.