Star Trek: 11 Things You Didn't Know About The Borg Queen
4. The Janeway Factor
Captain Janeway and the crew of Voyager had bounties of battles with the Borg Queen and yet, for the most part, avoided the nanoprobe treatment. As they hitched a transwarp ride back to the Alpha Quadrant, they even managed to decimate the Borg and destroy the (or at least one) Queen with just one hypospray (full of a neurolytic pathogen).
It was also thanks to Voyager that the research of pioneering exobiologists the Hansens was found. Around 18 years prior to the Enterprise-D's first reckoning with a cube in 2365, the couple had set off in search of the Borg. During their three years in the field before their eventual assimilation in 2350, the Hansens became aware of the existence of the Borg Queen and of her primary residence Unimatrix One.
"We think she's more like the queen of an insect colony. She helps coordinate all the other drones," Erin Hansen commented to the daughter she and her husband brought along for the ride in Voyager's Dark Frontier. Such knowledge was well in advance of the Federation who, we assume, only found out about the Borg Queen after the Enterprise-E returned to 2373.
Until recently, since her presumed 'death' at the hands of Admiral/Captain Janeway in Endgame, we hadn’t seen another prime version of the Borg Queen (aside from the hilariously holographic hindrance to Boimler perfection in the Lower Decks episode I, Excretus).
WELL, THAT was until the last two episodes of Star Trek: Picard season three (and prior, as a voice inside Jack Crusher’s head)!