1. Jed Bartlet and Leo McGarry (The West Wing)
Nothing says I love you, bro like telling your best friend you think he should run for president. With his Bartlett For America campaign, that's exactly what Leo McGarry did when he went to visit Jed Bartlet about a year before the upcoming election. Over the course of seven seasons and two terms, these two ran the country like clockwork or as damn close to clockwork as you can get when it comes to running a country. Jed was always the idealist in their partnership, Leo the calm but firm voice of reason. In a lot of ways, Leo was the natural politician, while Jed was a born leader and an economist. Despite being friends for over forty years, Leo only calls Jed by his name a handful of times in the entire series, always addressing him as Mr. President. There were certainly hitches in the road Jed's multiple sclerosis, Leo's alcoholism, an accusation of war crimes, a political assassination that rocked their conscience, a failed peace treaty between Israel and Palestine, a heart attack, a kidnapping and an assassination attempt to name a few but they ran the course. After Leo's heart attack, which Jed was partly responsible for, he was forced to step down as Chief of Staff but stayed on as a consultant and later became the running mate of Democratic Presidential Nominee Matthew Santos, earning the Vice Presidential nomination. John Spencer's unfortunate death during the filming of season seven led to this nomination never being fulfilled, but rather than working around this issue, the writers and crew embedded John's real life death with the death of his character, paying tribute to his legacy.
Best bromance moment: The last five minutes of 'Let Bartlet Be Bartlet'.