6. Dr. Curt Conners/Lizard in The Amazing Spider-Man (2012)
In an attempt to regenerate his amputated limb, Dr. Curt Conners (played by Rhys Ifans) went from trying to play God to looking like Godzilla instead... Dr. Curt Conners wasn't even a bad person to begin with, nor did he have any enemies. However, like many drugs and strong medication - there can be dangerous side-effects. In this case, Curt transformed into Lizard; a reptile humanoid monster with a bad temper and a tendency to dabble in destruction. Very reminiscent of the dynamic between duo Dr. Jekyll and Mr. Hyde indeed.