5. Sherlock Holmes and Dr. Watson, (Master Detective/Medical Doctor, around 50 collaborations)
Now the game is afoot...We continue with the Master of Deductive reasoning and his partner in crime, so to speak, who have been solving the most baffling mysteries on film since there has been film. Always ready for the next murderer to be caught, priceless jewel recovered or kidnapped returned, they were always a step ahead of even the best of Scotland Yard. Whenever Holmes' tendency to over-think or let his imagination run wild made him cloud his judgement was when Watson's keen grasp on reality truly aided the super sleuth, it is elementary after all. Thus, the pairing has survived through countless adaptions by filmmakers of all sorts. One of the most prolific fictional characters of all time the first known Holmes film was with Sherlock Holmes Baffled in 1900. The two were most memorably played by Basil Rathbone and Nigel Bruce in the series of movies that began in 1939 with The Hound of the Baskervilles. While, his incarnations vary from quietly controlled to constantly on the edge of sanity, what has remained the same is the rapport between these characters. It is the very reason why Sir Arthur Conan Doyle's mysteries continue to engage filmmakers to this day.