6. Sandman's Giant Punches (Spider-Man 3)
In the final fight scene in Spider-Man 3, Mary Jane Watson has been strung up by Venom's webbing at the top of a construction site. Sandman attacks Spidey in his gigantic form, having merged all the sand on-site with himself. Spidey dodges his attacks and heads up to rescue Mary Jane, but is cut off by Venom, who appears out of nowhere and slams him onto a metal girder. Venom then uses his webbing - which he wraps around Spidey's neck - to pin the hero to the girder, allowing Sandman to attack him without retaliation or any attempt to dodge the assault. Sandman forms a giant fist, which he hardens into what is essentially a large boulder, and proceeds to deliver a series of downward punches directly on to Spider-Man's prone body. It is a truly brutal and unforgiving attack but, fortunately, not one that does any real lasting damage to the webbed wonder, thanks to his incredibly durability.