Politically-charged thriller Syriana is apparently one of Harrison Ford's biggest career regrets, and it's easy to see why. Having been offered the lead role of Bob Barnes in Stephen Gaghan's 2005 effort, Ford decided against taking the part and instead watched George Clooney again step in to fill his shoes (much like Clooney had replaced Ford years prior on The Perfect Storm). The reasoning for Ford's decision was because he spent large parts of 2004, 2005 and 2006 acting as the Chairman of the Young Eagles program of Experimental Aircraft Association, although his absence didn't really do the film any harm. Sure, Ford could've ticked off some of the complex boxes that Clooney brought to the role, but smooth-talking George excelled as the CIA operative could in the middle of the politics involved in the petrol and oil industry. Clooney would go on to wow audiences as Gaghan's movie drew praise from all corners, with Ford having since openly talked about his regret at deciding against the picture.