5. Venom
The source material for Marc Webbs Spider-Man films is the Ultimate universe, a spinoff series retelling the origins of Marvels flagship characters for a new generation. From what I can tell, it keeps the names of these characters the same and changes almost everything else. Webb's franchise could certainly be headed toward Venom. Now technically, he was already used once, which makes him different from every other villain on this list. But his shameful appearance in Spider-Man 3 hardly counts. In that movie, Venom came off as one-dimensional as possible. While it is a singular motivation that keeps the character interesting his hatred of Peter Parker and Spider-Man its what Venom does to the wall-crawler that makes him such an enduring and terrifying character. In the version with which Im familiar, a living costume from an alien world bonded with Spider-Man who wore it for awhile and then rejected it, after which the suit found Eddie Brock whose hatred for Spider-Man matched the creatures own. Together, they became Venom and hounded Spider-Man relentlessly. Creator Todd Macfarlanes original depictions are genuinely creepy. With full knowledge of Spider-Man's secret identity, Venom stalked Peter Parker's loved ones and made his life a living hell. Simply killing Spider-Man isn't enough for Venom; torment is the name of his game. Anything Spider-Man can do, Venom can do better. Whatever origin story filmmakers ultimately give the character, its important that the magnitude of the terror he can inflict in Spider-Mans world be kept. He is the classic type of villain, a total inversion of the hero.