2. Harold Attinger - Transformers: Age Of Extinction
If you're a human and you get in the way of the Transformers, you're probably going to have a bad time: just look at Patrick Dempsey's turncoat character in the previous movie, who got in bed with the Decepticons and ended up being horribly electrocuted. This time the main human antagonist is Harold Attinger, a counter-intelligence operative played by Kelsey Grammer, who wants to bring the Transformers to their knees, possibly because of the destruction caused in Chicago at the end of the third movie. Short of the Autobots managing to talk Harold around (perhaps by saving his life), he'll probably bite the bullet, but that depends on how much of an antagonist he really is: will be ultimately strike a deal with the Decepticons? Or will he simply be trying to obliterate all of the Transformers? We'll have to wait and see, but he probably won't survive the movie.