SPOILERS for Spider-Man: No Way Home and Hawkeye
With Spider-Man: No Way Home, the first MCU Spider-Man trilogy has come to a tremendous close. Not only is it Sony's highest-grossing film of all time, but it's an all-around crowd-pleaser that hit all the right notes to appease Spider-fans of every generation.
At the end of No Way Home, Peter made the earth-shattering decision to have Strange cast a spell that wiped him from the world's collective memory. Now, Peter is at an all-time low. While a second MCU trilogy hasn't been officially confirmed (as of this publication), both Kevin Feige and Amy Pascal have stated that they're actively developing where the story will go for the as yet unnamed and unannounced Spider-Man 4.
Naturally, any discussion of Spider-Man films comes with speculation about what villains may be included. After all, Spider-Man has one of the greatest rogues galleries in all of comic-dom, rivaled only by that of Batman. So who might we see in the (presumed) forthcoming trilogy? We almost certainly won't see anyone we've seen before (with a few very probable exceptions). That takes Green Goblin, Sandman, the Lizard, Electro, Mysterio, and Doctor Octopus off the table.
Given the options that are off the table and where Peter's story left off, we've got quite a few interesting possibilities. Let's dive in.
12. Alistair Smythe
Granted, there have been no hints that we might see Smythe, but Sony apparently had plans for him at one point, as they featured him as a minor supporting character in The Amazing Spider-Man 2. Unless they pursue a third film, there'll be no revisiting that iteration of the character. He'd be a great fit for the MCU, though.
As established in No Way Home, Oscorp doesn't exist, and the Tinkerer is MIA. Sure, Marvel could keep beating the Stark tech drum, but eventually, that'll get stale. So who could provide high tech weaponry and gear to Spidey's foes? That could very well be Alistair Smythe.
Of course, wherever Alistair and his father, Spencer, are, there must also come the Spider-Slayers, an army of robots designed specifically to hunt down Spider-Man and... well... slay him. Even though no one remembers Peter Parker, Spider-Man is still very much a public figure, and people like J. Jonah Jameson are very publicly painting him as a murderer after his battle with Mysterio. Now Spider-Man is a faceless "public menace" with a target on his back. Smythe could be one of many people drawing a bead on that target.