The script of Ghostbusters went through many forms during pre-production. By the time Harold Ramis had tamed Dan Aykroyd's stranger proclivities and settled it down as a somewhat straight comedy, it was written as a Saturday Night Live film which would co-star Eddie Murphy (as Winston) and John Belushi (as Peter Venkman). Obviously that isn't what happened, for various clashing schedule/being dead reasons. When Ivan Reitman came on he decided he wanted to aim at a younger, more family-friendly audience, so a lot of the jokes got rewritten along with the characters. The graffiti on Venkman's door was meant to be more venomous and explicit but was swapped out for VENKMAN BURN IN HELL, a nod to the final scene in Carrie (1976) where those words appear on a real estate sign.
Tom Baker is the Comics Editor at WhatCulture! He's heard all the Doctor Who jokes, but not many about Randall and Hopkirk. He also blogs at http://communibearsilostate.wordpress.com/