50 Funniest Comedy Movie Moments Since 2000

The Movie: Described as a “sort-of sequel” to Knocked Up, given that it features two of that movie’s secondary characters as its leads, This is 40 follows the lives of middle-aged married couple Pete and Debbie (Paul Rudd and Leslie Mann) as they each turn 40, with their jobs and daughters adding stress to their relationship.

The Scene: After an argument and some inadvertent nipple poking, Pete and Debbie find themselves in the principal's office with another parent, Catherine (Melissa McCarthy), who complains about their daughter harassing her son. This leads to Catherine flipping out and threatening to kick the couple in the jaw with her "foot bone".

Memorable Quote: "I'm quoting! How am I gonna relay what these two nutballs said to me unless I say it?"