5. Killing off Gwen Stacy
Fincher states up front that he would have the Green Goblin kill Gwen Stacy in the film. While her death wouldn't be a total surprise since her death is one of the most iconic moments in Spider-Man's mythology, killing off the main character's love interest would still be a bold move for a superhero movie. It'd also be a incredibly moving moment that goes past the spectacle to the tragic heart of the Spider-Man character.