4. Juliette Lewis And Ethan Suplee
Relation: Sister-In-Law Ethan Suplee, the actor famous for playing the dimwitted brother of Jason Lee's Earl in My Name Is Earl, as well as numerous other film roles, is married to Brandy Lewis: Juliette Lewis' sister. What profession Suplee's wife works in is unclear, but considering that there's little record of her professional life, it's probably safe to assume that she isn't an actor like her husband and sister. Suplee and his sister-in-law couldn't be further apart in terms of the film roles they're both known for, but there is at least one instance where the two have appeared on-screen together. Juliette Lewis guest stars in a single episode of My Name Is Earl, in which she plays a bounty hunter hell-bent on revenge on Earl's ex-wife, Joy, for knocking her teeth out years prior to the events of the TV series. There's even a scene where Lewis holds her dear brother-in-law captive in his own bedsit.