Avengers 4: 10 Most Likely Characters To Be Killed
4. Pepper Potts
Much like War Machine, Pepper Potts is probably in trouble because of what her death would represent to Tony Stark - especially now that they're said to be engaged in Infinity War (despite how Spider-Man: Homecoming ended).
Tony's biggest fears centre around his inability to protect those he loves (as well as the entire world) and when Thanos turns up Iron Man needs a reminder that the Avengers are better together and that his life choices endanger those around him. That's already been a major thread in the MCU without it really being explored too overtly and this would be the perfect time to pull the trigger on something this devastating.
It might be slightly unfair on Pepper, since she's never had a great deal to do, but for Tony's whole story it's a good idea.